Download e-book for kindle: Nucleic Acid Polymerases by Katsuhiko S. Murakami, Michael A. Trakselis

By Katsuhiko S. Murakami, Michael A. Trakselis

ISBN-10: 3642397956

ISBN-13: 9783642397950

ISBN-10: 3642397964

ISBN-13: 9783642397967

This publication presents a evaluation of the multitude of nucleic acid polymerases, together with DNA and RNA polymerases from Archea, micro organism and Eukaryota, mitochondrial and viral polymerases, and different really good polymerases resembling telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. even if many books conceal a number of types of polymerases, no booklet up to now has tried to catalog all nucleic acid polymerases. The target of this publication is to be the pinnacle reference paintings for postgraduate scholars, postdocs, and precept investigators who examine polymerases of all types. In different phrases, this ebook is for polymerase enthusiasts by means of polymerase fans.

Nucleic acid polymerases play a primary function in genome replication, upkeep, gene expression and legislation. all through evolution those enzymes were pivotal in remodeling lifestyles in the direction of RNA self-replicating structures in addition to into extra reliable DNA genomes. those enzymes are normally tremendous effective and exact in RNA transcription and DNA replication and percentage universal kinetic and structural positive factors. How catalysis should be so amazingly speedy with out lack of specificity is a query that has intrigued researchers for over 60 years. sure really expert polymerases that play a severe position in mobile metabolism are used for varied biotechnological functions and are as a result a vital software for research.

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081088798 Walter J, Newport J (2000) Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell 5 (4):617–627. 1016/S1097-2765(00)80241-5 Wang Y, Zhang Q, Chen H, Li X, Mai W, Chen K, Zhang S, Lee EYC, Lee MYWT, Zhou Y (2011) P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA. PLoS One 6(11):e27092. doi: 10. 0027092 Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF (2009) Physical interactions between Mcm10, DNA, and DNA polymerase alpha.

Biochemistry 30(51):11751–11759. 1021/bi00115a003 Thompson HC, Sheaff RJ, Kuchta RD (1995) Interactions of calf thymus DNA polymerase alpha with primer/templates. Nucleic Acids Res 23(20):4109–4115 Tsubota T, Maki S, Kubota H, Sugino A, Maki H (2003) Double-stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase epsilon and of the Dpb3p-Dpb4p subassembly. Genes Cells 8 (11):873–888. 00683 Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M, Yagi T (2009) DNA polymerase delta is required for early mammalian embryogenesis.

4 A Highly Accurate Polymerase Pol ε is perhaps the most accurate eukaryotic DNA polymerase. Purified calf thymus Pol ε base substitution error rates determined in vitro ranged from 1/30,000 to 1/400,000 mutations per nucleotide synthesized, lower than either Pol δ or Pol α (Thomas et al. 1991). The S. c. Pol ε holoenzyme exhibits very low base substitution and single-base deletion error rates, 2 Â 10À5 and 5 Â 10À7 (Shcherbakova et al. 2003), respectively. Error rates of human Pol ε have not yet been determined because they are close to background rates for in vitro mutation assays (Korona et al.

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Nucleic Acid Polymerases by Katsuhiko S. Murakami, Michael A. Trakselis


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