By Sergei D. Varfolomyev, Gennady E. Zaikov
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Additional info for Molecular Polymorphism of Man: Structural and Functional Individual Multiformity of Biomacromolecules
A. Gariev Recently, great attention is paid to ACHE physiological functions not related to cholinergic transmission [59, 60]. The role of ACHE in stimulation of nerve and muscle cell proliferation has been shown. ACHE may be a marker of early differentiation of cells. Recently, correlations between change of activity of this enzyme and development of some widespread diseases, cardiovascular system [61-64], atherosclerosis , Parkinson‘s and Altzheimer‘sAlzheimer‘s diseases [61, 66], in particular, have been determined.
Table 7 summarizes information on the replacements for cyclooxygenases described. It should be noted that phenotypically sufficient replacements in COX-1 are the ones by hydrophobic amino acids. In all cases, replacements by hydrophilic amino acids give no sufficient phenotypic effects. Table 7. 35 hydrophobic property by relative units by OHM scale, positive values correspond to hydrophobic AA and negative to hydrophilic AA. the probability that over 5% of AA molecule surface contacts with solution surrounding the protein.
Note that in 7 of 9 cases, AA transformation at gene mutation increases hydrophobic property. 5 times for Leu335Pro) reduce the enzyme stability. Amino acids observed either import positive charge to the protein structure or do not change it. Figure 4. The structure of human butyrylcholinesterase. The places of amino acid replacements described resulting single enzyme gene mutations are indicated. Table 2. 65 hydrophobic property by relative units by OHM scale, positive values correspond to hydrophobic AA and negative to hydrophilic AA.
Molecular Polymorphism of Man: Structural and Functional Individual Multiformity of Biomacromolecules by Sergei D. Varfolomyev, Gennady E. Zaikov