By Alberts, Johnson, Levis, Raff
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Additional resources for Molecular Biology Of The Cell
It must also express its information, putting it to use so as to guide the synthesis of other molecules in the cell. This also occurs by a mechanism that is the same in all living organisms, leading first and foremost to the production of two other key classes of polymers: RNAs and proteins. The process begins with a templated polymerization called transcription, in which segments of the DNA sequence are used as templates to guide the synthesis of shorter molecules of the closely related polymer ribonucleic acid, or RNA.
This directionality guides the molecular processes by which the information in DNA is interpreted and copied in cells: the information is always "read" in a consistent order, just as written English text is read from left to right. (C) Through templated polymerization, the sequence of nucleotides in an existing DNA strand controls the sequence in which nucleotides are joined together in a new DNA strand; T in one strand pairs with A in the other, and G in one strand with C in the other. The new strand has a nucleotide sequence complementary to that of the old strand, and a backbone with opposite directionality: corresponding to the GTAA...
Genes of this latter sort are therefore highly conserved. 5 billion years or more of evolutionary history, many features of the genome have changed beyond all recognition; but the most highly conserved genes remain perfectly recognizable in all living species. These latter genes are the ones that must be examined if we wish to trace family relationships between the most distantly related organisms in the tree of life. The studies that led to the classification of the living world into the three domains of bacteria, archaea, and eucaryotes were based chiefly on analysis of one of the ribosomal RNA subunits the so-called 16S RNA, which is about 1500 nucleotides long.
Molecular Biology Of The Cell by Alberts, Johnson, Levis, Raff