By B. Singer, D. Grunberger (auth.)
This publication originated in several Gordon examine meetings and plenty of different conferences of scientists operating in chemistry, biophysics, biochemistry, and biology on the topic of mutagenesis and carcinogenesis. It appeared the appro priate time to relax and summarize the result of a number of many years of analysis in laboratories in numerous nations. we're very thankful to the Rockefeller beginning for inviting us to formulate and start writing the booklet on the middle for foreign reports in Bellagio, Italy, the place we have been Resident students. we're lucky to have had the help of such a lot of colleagues world wide who cheerfully despatched unique info, figures, and preprints and lis tened patiently to us as we labored out a few of the conflicting principles during this fast-moving. box. The names of those scientists are chanced on in the tables, figures, and references. there's one individual whose contributions we specially desire to acknowl area. Professor Heinz Fraenkel-Conrat was once current on the inception of this booklet and through the writing inspired and criticized in nearly equivalent percentage. eventually, his enhancing and amalgamation of our kinds gave us nice convenience. B.S. D.G.
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Additional info for Molecular Biology of Mutagens and Carcinogens
This would prevent Watson-Crick basepairing (although monomer interactions are not restricted to Watson-Crick pairing). Nevertheless, experimentally, Watson-Crick pairing occurs in poly(V, N4-methoxy C) complexed with poly(A), as shown by mixing curves (Figure III-7). Vnlike (V, C) copolymers, poly(V, N4-methoxy C) annealed with poly(A) on a 1 : 1 basis, indicating that the modified C was held within the helix. Watson-Crick basepairing was shown by cooperative melting of the annealed complex. An example of a "frozen" tautomer of a purine.
And their components. In Organic Chemistry of Nucleic Acids, Part B (N. K. Kochetkov and E. ), Plenum Press, New York, pp. 477-532. Kochetkov, N. , Budovskii, E. , Sverdlov, E. , Simukova, N. , Turchinskii, M. , and Shibaev, V. N. (1972) Hydrolysis of N-glycosidic bonds in nucleosides, nucleotides, and their derivatives. In Organic Chemistry of Nucleic Acids, Part B (N. K. Kochetkov and E. I. ), Plenum Press, New York, pp. 425-448. , and Shugar, D. (1979) Methylation and tautomerism of I-substituted 5-fluorocytosines.
And Grant, C. L. (1982) Stability of the DNA apyrimidinic site. Mutat. Res. 103, 101-106. Fersht, A. Roo and Knill-Jones, J. W. (1981) DNA polymerase accuracy and spontaneous mutation rates: Frequencies of purine . purine, purine . pyrimidine, and pyrimidine' pyrimidine mismatches during DNA replication. Proc. Natl. Acad. Sci. USA 78, 4251-4255. Fersht, A. -c. (1983) Kinetics of base misinsertion by DNA polymerase I of Escherichia coli. J. Mol. Bioi. 165, 655-667. 44 CHAPTER III Fresco, J. -E.
Molecular Biology of Mutagens and Carcinogens by B. Singer, D. Grunberger (auth.)