By Fred A. Kincl Ph.D., DSc., FRSC (auth.)
The account of "neonatal sterilization" is the tale of the advocates of direct impact of steroids at the gonads and people who believed within the oblique effect, mediated in the course of the hypothalamus and/or the pituitary gland. As frequently occurs in biology, either convictions symbolize an analogous picture noticeable from varied views. Prof DC Johnson (Kansas urban, KS) reminisced the start of the tale in a letter to me. i'm paraphrasing components of the letter together with his permission. "As a place to begin shall we choose the life-long learn of Emil Steinach ... " Steinach well-known the impact of testes at the improve ment of accent intercourse organs in 1894, defined virilization of adult females and feminization of men in 1913, and pointed out the controlling effect of the hypophysis at the gonads in 1928. He reviewed his paintings in a booklet intercourse and lifestyles, 40 Years of organic and scientific adventure (E Steinach and L Loebe!; Faber and Faber, London, 1940). He acquired at the unsuitable highway in later years and that's all people turns out to have forgotten him. He awarded his speculation that estrogen has an instantaneous influence upon the testes, i. e. hormone antagonism, on the 1st overseas Congress on intercourse examine in 1926.
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Extra info for Hormone Toxicity in the Newborn
1985) suggested that a portion of the human 22 2 Control of Reproductive Function in the Adult placental precursor of GnRH, a 56 amino acid peptide (GnRH associated peptide), may be the hypothalamic inhibitory factor. , 1984). The posterior pituitary contains a polypeptide of less than 5 kD which stimulates PRL secretion from perfused anterior pituitary cells in the presence of physiological concentrations of dopamine (Hyde and Ben-Jonathan, 1988). , 1987). Greef et al. (1987) believe thyrotropin releasing hormone (a tripeptide), not serotonin, is the releasing agent.
4 Melanocyte Stimulating Hormone (Melanotropin, MSH) The concentration of MSH rises and falls during the estrus cycle in patterns similar to those of LH, FSH and PRL (Tomatis and Taleisnik, 1969; Celis, 1975). In rats the hormone may act in synergism with LH and/or progesterone to induce ovulation (AIde and Celis, 1980) or may potentiate the effect of fJ-endorphin in inhibiting LH secretion (Khorram and McCann, 1986). , 1985). 1 Males The testes are paired structures formed of about 30 coiled seminiferous tubules and interstitial tissue formed of connective tissue and interstitial (Leydig) cells.
1986) state that LH appears in blood within two minutes. Rapid fluctuation of hormone levels in blood does not present a danger that the endocrine tissue could become depleted. The concentration of hormones in the respective endocrine glands usually surpasses manyfold the quantity released. It has been estimated that in the rat less than 5% of the available GnRH is released during each episode. The amount released is in excess of the physiological need. Kalra et al. (1971) approximate that only about 15% of LH released during a preovulatory surge is needed for ovulation.
Hormone Toxicity in the Newborn by Fred A. Kincl Ph.D., DSc., FRSC (auth.)