By Michael Hensel, Herbert Schmidt
Horizontal gene move is an important motive force within the evolution of many bacterial pathogens. the advance of high-throughput sequencing instruments and extra subtle genomic and proteomic strategies in recent times has led to a greater knowing of this phenomenon. Written by way of best specialists within the box, this edited quantity is aimed toward graduate scholars and researchers and offers an outline of present wisdom in terms of the evolution of microbial pathogenicity. This quantity presents an outline of the mechanisms and organic results of the genome rearrangements because of horizontal gene move, in either prokaryotes and eukaryotes, in addition to overviews of the most important cellular genetic components concerned. next chapters specialize in paradigms for the evolution of significant bacterial pathogens, together with Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The impression of socioeconomic parameters within the dissemination of transferable parts, comparable to antibiotic resistant genes in micro organism is additionally mentioned.
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Additional info for Horizontal Gene Transfer in the Evolution of Pathogenesis (Advances in Molecular and Cellular Microbiology)
Lawrence, J. , Roth, J. , and Charlebois, R. L. (1999). Genomic flux: genome evolution by gene loss and acquisition. Washington, DC: American Society for Microbiology. , Ptacin, J. , Pease, P. , et al. (2005). Identification of oligonucleotide sequences that direct the movement of the Escherichia coli FtsK translocase. Proc Natl Acad Sci USA, 102, 17618–23. Lobry, J. , and Sueoka, N. (2002). Asymmetric directional mutation pressures in bacteria. Genome Biol, 3, RESEARCH0058. Lovegrove, F. , et al.
Individual lineages do not necessarily contribute to, or draw their DNA from, a single mating pool, and therefore can diverge considerably in the composition of the DNA that they have acquired. 79034in May 23, 2008 14:12 recombination is thus variable and interesting. In this review we first describe features of the biology of exchange that promote differences in patterns and rates of recombination between different strains. Second, we review the evidence for gross differences in recombination rates between bacteria from different genera, as estimated using a variety of experimental approaches.
Finally, we discuss how we might go about acquiring a systematic knowledge of bacterial recombination patterns in nature. 2. BACTERIAL MECHANISMS OF EXCHANGE ALLOW ENORMOUS VARIABILITY IN RECOMBINATION RATES Bacterial recombination is the process by which foreign DNA is inserted in the bacterial genome. This always happens in two steps: first a molecule of DNA is taken into the bacterial cell, and then this molecule (or some parts of it) is inserted in the genome. Transformation is the process by which naked DNA from the external environment is incorporated into a bacterial cell.
Horizontal Gene Transfer in the Evolution of Pathogenesis (Advances in Molecular and Cellular Microbiology) by Michael Hensel, Herbert Schmidt