By Professor Jean Bernard (auth.), Marcel Bessis, George Brecher (eds.)
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Additional resources for Hemopoietic Dysplasias (Preleukemic States)
Some cells are normal, while others may be intermediate in their abnormal character . Classification - Nomenclature Classification of PL remains imperfect and is based mainly on quantitative and qualitative criteria derived from bone marrow studies or in some cases on biological data or both. Thus the following diseases or syndromes can be described: 1. Aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), primary acquired sideroblastic anemia (PASA). For each of these well-established syndromes, the emergence of AL has been described.
Ser. Haemat. 3, 3, 1972 25. : Foreword and a proposal for considering paroxysmal nocturnal hemoglobinuria (PNH) as a candidate myelo-proliferative disorder. Blood 33, 263, 1964 26. : The Di Guglielmo syndrome revisited. Blood 34, 567, 1969 27. : Analyses chromosomiques dans I'anemie sideroblastique idiopathique acquise. Nouv. Rev. Fr. Hemat. 6, 367, 1966 28. ,: Anemies rHractaires, etats pre-Ieucemiques et anomalies enzymatiques multiples. R. A cad. , (Paris), S6rie D, 236, 1627, 1968 29. : Anemies rHractaires: enzymopathies acquises des cellules souches hematopoietiques.
Clinical· investigations typically reveal no enlargment of the lymph nodes, spleen, or liver. Examination of smears or sections of bone marrow (BM) show different patterns. BM may show hypo- or aplasia, normoplasia, or even hyperplasia of a cell line or lines whose level is reduced in the blood. These aspects in the BM may be variously combined. For example, anemia with leukopenia may show erythroblastic aplasia with concomitant hyperplasia of granulocyte precursors. An excess of the more juvenile cells of the line is frequent when the BM is normoplastic or hyperplastic.
Hemopoietic Dysplasias (Preleukemic States) by Professor Jean Bernard (auth.), Marcel Bessis, George Brecher (eds.)