By J. Escalona-Zapata (auth.), Julio H. Garcia M.D., Julio Escalona-Zapata M.D., Uriel Sandbank M.D., Jorge Cervós-Navarro M.D. (eds.)
Every 12 months dozens of physicians-in-training face, for the 1st time, the responsibil ity of studying and diagnosing crucial worried approach tumors or biopsies of the primary apprehensive process, the peripheral nerves or muscular tissues, whose surgical resection has been selected either as a sort of therapy (in the case of tumors) and as potential to verify a presumptive analysis. the choice of the main acceptable type of put up surgical procedure for many tumors is based at the specific id of the tumor cells. The evaluate of the specimen, by way of a pathologist, won't in simple terms be sure no matter if the lesion is actually neoplastic, but additionally no matter if there are histologic signs of malig nancy. in addition, every so often, the pathologist might be requested to figure out no matter if the tumor cells include definite hormone precursors or receptors, for example. popularity of the various gains that one needs to look for calls for the really appropriate program of tools that will not be effectively recognized to the physicians eager about a number of the diagnostic systems. The dealing with and processing of the tissues as they come within the pathology laboratory for the above purposes fluctuate as a functionality of the organ (or web site) of foundation of a given tumor in addition to a functionality of the presumptive medical analysis. the cloth contained during this ebook sequence has been geared up in an try to aid the pathologists-in-training, the overall pathologists, the neurosurgeons, and neu rologists to appreciate the common sense in the back of such targeted requirements.
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Extra resources for Diagnostic Neuropathology: Volume II
Boston, Butterworths, 1977 93. Willmer EN: Morphological problems of cell type, shape and identification, in Willmer (ed); Cells and Tissue in Culture, Vol. 1. Academic Press, Orlando, Florida 1965 pp. 143-176 94. Wilson CB, Barker M, Slagel DE: Tumors of the central nervous system in monolayer culture. Arch Neuro/15:275-282, 1966 6 Brain Biopsy f. H. Garcia f. Cerv6s-Navarro Introduction Because of ethical implications, a decision to biopsy the brain must be considered carefully by the patient (if capable of making the decision), the next of kin, the neurologist, the surgeon, and the pathologist.
Fusiform-shaped cells with long processes and oval nuclei predominate in this case. A group of macrophages is visible at the left upper comer. (H&E, X200) Inset: Histologic image of the original tumor. (H&E, x lOO). 42 f. Escalona-Zapata • Fig. 5-40. Schwannoma of the cerebellopontine angle after 12 days of culture. Stellate cells and macrophages predominate in this case. There is a transition between the bipolar elements and the round macrophagic elements. (H&E, x 200). to the ameoboid pattern of Wilmer (Fig.
The cells are bipolar, become progressively larger, and acquire more cytoplasm as seen in the circular structure to the right of the field. ) Inset: Histologic preparation of the original tumor ( x lOO). HEMANGIOBLASTOMA Within the mesenchymal brain tumors, the main attraction in the application of tissue culture to the study of hemangioblastoma resides in the study of the cell(s) of origin. Unfortunately, tissue cultures have contributed little to answer this question. Few publications on this subject have appeared.
Diagnostic Neuropathology: Volume II by J. Escalona-Zapata (auth.), Julio H. Garcia M.D., Julio Escalona-Zapata M.D., Uriel Sandbank M.D., Jorge Cervós-Navarro M.D. (eds.)