By D. Weedon (auth.), Colin Leonard Berry (eds.)
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Another study provided a possible explanation by finding that ulceration of the primary tumour resulted in a progressive increase in the number and area of lymph node germinal centres (WEIDNER et al. 1982). Germinal centre activity was found to increase as melanoma progressively invaded the node (LEWIS et al. 1979). 11 Size and Shape Although patients with melanomas greater than 1-2 em in diameter (the upper limit varies in the different reports) have a worse prognosis than patients with smaller lesions (Huvos et al.
Although the overall five year survival in males and females with clinical stage 2 disease was similar in one study (SHAW et al. 1982), if patients were matched for thickness and age, a female superiority did exist for young patients with very thick lesions . 17 Age Younger patients have a significantly better prognosis than older patients (ELDH et al. 1978). It has been suggested that this effect arises largely from the superior Melanoma and Other Melanocytic Skin Lesions 39 survival of young females, although this was not confirmed in a recent study (BLOIS et al.
85 mm using the proposals of DAY et al. (1981 b)) are increasing in overall proportion, with earlier diagnosis and treatment of malignant melanomas (BAGLEY et al. 1981 ; GRIFFEL 1981; BALCH et al. 1983). Thin melanomas are more common in high incidence populations than low incidence ones , probably because of earlier recognition in areas with a high incidence (LEMISH et al. 1983). The proportion of thin melanomas has been as high as 35 to 57% in some reports (SHAFIR et al. 1982 ; LEMISH et al. 1983 ; TRAU et al.
Dermatopathology by D. Weedon (auth.), Colin Leonard Berry (eds.)