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ISBN-10: 1634832825

ISBN-13: 9781634832823

Deep mind stimulation (DBS) is now a well-established remedy of Parkinson’s disorder,
essential tremor, dystonia and obsessive compulsive problems. as a result of its luck, it is
constantly investigated in different stipulations, and the record of FDA authorized symptoms is likely
to develop quickly.
Its luck stems primarily from its reversible nature in comparison to the damaging lesions
created in the course of thalamotomy and pallidotomy, and from its flexibility via programming
that permits amendment of the strength dropped at the categorical mind ambitions so one can obtain
maximal profit with minimum unwanted side effects.
This ebook was once conceived as a complete, but useful consultant for any physician
interested during this existence altering remedy. It covers the entire points of DBS together with: a historical
review; the underlying neurophysiologic mechanism of therapy; intra-operative information from
the neurosurgical and the neurophysiologic point of view; a evaluation of the facts supporting
the use of deep mind stimulation for every illness; algorithms for sufferer selection,
programming ideas; and troubleshooting and potential symptoms.
Written by means of specialists within the box from diverse global well known associations, it provides a
unique and complete perception into the universe of DBS.
We wish it will likely be a worthy source for all healthcare execs curious about the
management of sufferers with DBS.

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Extra info for Deep Brain Stimulation

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Internal pulse generators from both manufacturers are classified into three main categories – single channel, dual channel, and rechargeable devices. Single Channel Internal Pulse Generator These devices provide stimulation to one single deep brain stimulation lead. Hence, a single channel internal pulse generator has less volume of hardware and requires a smaller sized battery. Given its compact size, it is most suitable for patients with a lean body mass. 36 Aasef G. Shaikh and Hubert H. Fernandez The other advantage of a single channel pulse generator is that, because one internal pulse generator is responsible for modulating one lead, in cases of malfunction of one internal pulse generator during bilateral deep brain stimulation, the second side would remain functional.

The number and location of axons that are stimulated can be adjusted by changes in the voltage. Higher voltages can stimulate more axons by increasing the spatial extent of the electrical field intensities. Within the electrical field, increasing the voltage can increase the number of axons stimulated. The type of axon that is stimulated can be manipulated by changes in the pulse width. 40 Aasef G. Shaikh and Hubert H. Fernandez The electrode is here placed in the Vim for illustration. C+: the neurostimulator is used as the anode.

In: Deep Brain Stimulation Editor: Raja Mehanna ISBN: 978-1-63483-282-3 © 2015 Nova Science Publishers, Inc. Chapter 2 BASAL GANGLIA PHYSIOLOGY AND DBS FOR PARKINSON’S DISEASE: INTRODUCTION AND POSTULATED MECHANISMS Pornpimol Anprasertporn MD, Neda Hidarilak MD and Harrison Walker MD University of Alabama at Birmingham, Birmingham, AL, US ABSTRACT After reviewing the historical development of deep brain stimulation (DBS) as a therapy in the first chapter, and before we dive into its clinical applications in different disorders, we will here review the motor circuitry of the basal ganglia, how it is dysfunctional in Parkinson’s disease, then the postulated mechanism of action of DBS.

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Deep Brain Stimulation

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