By David A. Cheresh (auth.), Brian W. Metcalf, Barbara J. Dalton, George Poste, Judy Schatz (eds.)
The books during this acclaimed sequence supply built-in, severe surveys of subject matters of present curiosity to the pharmaceutical undefined. Cellular Adhesion: Molecular Definition to healing Potential covers the molecular definition of adhesion molecule constitution and serve as, the organic effects of mobile adhesion, and the healing strength of concentrating on adhesion molecules.
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Extra resources for Cellular Adhesion: Molecular Definition to Therapeutic Potential
The asparagine designated with * (N single-letter code) in Fig. 9 has been shown to be important for focal contact formation (Reszaka and Horowitz, 1991). Thus, this asparagine may be misaligned in ~5 because of this putative insert. Alternatively, it is conceivable that specific residues within this particular domain enable ~5 to associate with other molecules within the cytoplasm; it would thus not be available to interact with the actin cytoskeleton, as observed with ~1 and ~3 integrins. To test this hypothesis it will be necessary to examine the expression of truncated and/or chimeric integrin heterodimers in cells that normally fail to form focal contacts on a vitronectin substrate.
Immunol. 148:1080-1085. , 1987, Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. J. Exp. Med. 166:1685-1701. , Rudloff, H. , Hillman, G. , and Anderson, D. , 1986, Two-dimensional and three-dimensional movement of human polymorphonuclear leukocytes: Two fundamentally different mechanisms of locomotion, J. Leukocyte BioI. 40:677-691. , 1994, Concepts in adhesion regulation, in: Handbook of Immunopharmacology: Adhesion MoLecules (c.
Random, nonspecific migration (when BSA is placed into the lower chamber), which has been subtracted, was $7% of the total migration in response to any substrate. 20 MOLECULAR DEFINITION bility that avJB and avJ35 mediate different biological signals in response to vitronectin. This report provides several lines of evidence that these integrins mediate distinct biological responses to a vitronectin substrate. , 1989a), attach but fail to spread on vitronectin, and are incapable of attaching to fibrinogen.
Cellular Adhesion: Molecular Definition to Therapeutic Potential by David A. Cheresh (auth.), Brian W. Metcalf, Barbara J. Dalton, George Poste, Judy Schatz (eds.)