Read e-book online Bone Marrow Transplantation and Other Treatment after PDF

By H Balner M.D. (auth.)

ISBN-10: 9024720567

ISBN-13: 9789024720569

ISBN-10: 9401011133

ISBN-13: 9789401011136

Acute radiation damage in guy has been amply reviewed some time past a long time (1-8). info for these experiences was once usually derived from the Hiroshima and Nagasaki adventure (3), from radiation injuries as a con­ series of trying out nuclear guns and the appliance of nuclear power (9-13) and from the intentional irradiation of sufferers, in general for the remedy of malignancies and/or as conditioning for transplantation (14-20). extra, a wide physique of knowledge derived from animal experimentation has ended in wary extrapolations to the human state of affairs (14). An difficult overview facing early somatic results of radiation in a guy was once released by way of UNSCEAR ) in 1962 (2). It used to be supplemented in 1969 with an identical record dealing quite often with radiation-induced chromosome aberra­ tions, the results of radiation at the frightened procedure and, radio-active illness of our environment by means of nuclear trying out (21). In a more moderen UNSCEAR record (1972) the most issues have been genetic results, carcinogenesis and results of radiation at the immune reaction (22). The early results of radiation in guy have been additionally expertly and comprehensively reviewed in a document by means of the U.S. nationwide examine Council in 1967 (23).

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Read or Download Bone Marrow Transplantation and Other Treatment after Radiation Injury: A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research) PDF

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Download e-book for kindle: Bone Marrow Transplantation and Other Treatment after by H Balner M.D. (auth.)

Acute radiation harm in guy has been amply reviewed some time past a long time (1-8). info for these stories was once commonly derived from the Hiroshima and Nagasaki event (3), from radiation injuries as a con­ series of checking out nuclear guns and the applying of nuclear strength (9-13) and from the intentional irradiation of sufferers, in most cases for the remedy of malignancies and/or as conditioning for transplantation (14-20).

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Extra resources for Bone Marrow Transplantation and Other Treatment after Radiation Injury: A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research)

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They include: the number of bone marrow cells injected. As a generalization, it can be said that the number of autologous or ~s~g~n~i£ bone marrow cells required for a functional take is approximately similar for 7 all mammalian species (3 - 5 x 10 cells/kg). The number of ~llo~ ~e~e~c cells required, is about 10 times higher, for most species (95). Estimates of the number of cells/kg body weight for a few species are presented in table V. For allogeneic combinations "within" a particular species, the required cell number will obviously depend on the degree of histocompatibility between donor and host.

Isog. 80 10 10 8 8 8 8 8 16 )25 The figures in this table represent the numbers of isogeneic, autologous and allogeneic bane marraw cells required ta provide 100 per cent thirty-day survival or maximum achievable protection following lethal whole body irradiation in various species. For the monkey the criterion in case of allogeneic bone marrow, was not 30-day survival but a "take". Adapted from a table which appeared in ref. 95 (page 319). The Graft versus Host (GvH) reaction. Table IV indicates that autologous or isogeneic bone marrow grafts are most easily accepted and do not lead to immunological complications.

49 both. The final conclusion had to be that GvHD was too great a hazard if MHC-non-identical donors were used. In the past decade, the methods of "conditioning" the patients for grafting were gradually changed. In 38 patients (24 with aplasia, 14 with leukemia) conditioning was done with ALS only. This approach drastically reduced the incidence of GvHD, but takes occurred less frequently and were usually temporary and "partial" (15). Drawing conclusions from the Paris data is rather difficult.

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Bone Marrow Transplantation and Other Treatment after Radiation Injury: A review prepared for the Commission of the European Communities, Directorate-General Research, Science and Education (Biology-Medical Research) by H Balner M.D. (auth.)


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