By Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)
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Additional resources for Biology of Renal Cell Carcinoma
A nonpapillary renal cell carcinoma should be diagnosed as a malignant tumor irrespective of size and grade. Patients with papillary renal cell carcinoma have a high risk for development of second or third tumor, whereas patients with a sporadic nonpapillary renal cell carcinoma generally do not. The difference in the genetics, especially after cloning the genes associated with the development of distinct types of tumors and with their progression, will have a strong impact on future molecular therapy.
J Uro1148: 1778-1782, 1992. 16. Blay J, Negrier S, Combaret V, et al. Serum level of interleukin 6 as a prognostic factor in metastatic renal cell carcinoma. J Uro152: 3317-3322, 1992. 17. Robbins PD, Horowits 1M, Mulligan RC. Negative regulation of human c:fos expression by the retinoblastoma gene product. ); 346: 668-671, 1990. 18. Pietenpol JA, Munger K, Howley PM, Stein RW, Moses HL. Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor, P1 and by the retinoblastoma gene product.
Expression of transfonning growth factor ex and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue. Cancer Res 49; 3407-3411, 1989. 12. Petrides PE, Bock S, Dovens J, Hoffmann R, Jakse G. Modulation of pro-epidermal growth factor, pro-transfonning growth factor ex and epidermal growth factor receptor gene expression in human renal carcinomas. Cancer Res 50: 3934-3939, 1990. 13. Miki S, Iwano M, Miki Y, et al. lnterleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas.
Biology of Renal Cell Carcinoma by Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)