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By Jesse P. Greenstein (Auth.)

ISBN-10: 1483231402

ISBN-13: 9781483231402

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Extra resources for Biochemistry of Cancer

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The laboratory procedures inevitably suggested the possibility that cancer may arise spontaneously in an animal through analogous procedures involving an abnormal metabolism of the bile acids or of other natural compounds of related structure. There is no proof whatever for such an assumption but it may be kept in mind as a perhaps far-fetched possibility. III. EXTRINSIC FACTORS 37 Another group of compounds studied by the English workers was that derived from 3,4-benzphenanthrene (7). The parent compound 3,4-Benzphenanthrene is very weakly carcinogenic but the 2-methyl-, 2-ethyl-, and 1-methylderivatives were active in producing epitheliomas (7).

Before passing to this discussion it might be advisable at the very beginning to define what is meant by a carcinogenic agent. Obviously, reference is made to an agent which will produce cancer in an animal, but this is far from the whole story, for the animal itself participates in the process. An agent may induce tumors predominantly of connective tissue (sarcomas) in one strain of mice, predominantly epithelial tumors (carcinomas) in another strain, and neither kind of tumor in still a third strain.

3 , 227 (1942) EARLE, W. , J. Natl. Cancer Inst. 4, 165 (1943) EARLE, W. , J. Natl. Cancer Inst. , and EARLE, W. , J. Natl. Cancer Inst. , J. ExpU. Med. , Brit. J. Exptl. Path. , J. Exptl. Med. 70, 257 (1939) (30) SANDISON, J. C , Am. J. Anat. 4 1 , 447 (1928) (31) CLARKE, E . , KIRBY-SMITH, H . , R E X , R. , and WILLIAMS, R. , Anat, Record 47, 187 (1930) (32) E B E R T , R. , FLOREY, H. , and PULLINGER, B. , J. Path. Bad. 4 8 , 79 (1939) (33) WILLIAMS, R. , Anat. Record 60, 493 (1934) (34) ALGIRE, G.

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Biochemistry of Cancer by Jesse P. Greenstein (Auth.)


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