Read e-book online Aliphatic and Polyhalogenated Carcinogens. Structural Bases PDF

By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos

ISBN-10: 0120593238

ISBN-13: 9780120593231

Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer causing agents of commercial origins.
The e-book discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and comparable aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and similar compounds thiocarbonyl compounds also are encompassed. The booklet extra tackles the structure-activity relationships, metabolism, and environmental value if fatty acids, detergents, and different surfactants with oncogenic capability. The textual content then appears into the impact of chemical reactivity, molecular geometry, and metabolism on carcinogenic task.
Chemists, geneticists, and people fascinated about melanoma examine will locate the booklet worthy.

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Sample text

In the halobutene group the correlation between direct-acting mutagenicity and allylic structure is also quite evident. In the study of Neudecker et al. (72) the mutagenic potency of six halobutenes follows the order (in the absence of metabolic activation): l-chloro-2-butene > 3-chloro-l-butène > 2-methyl-3-chloro-1-butène > l-chloro-2-methyl-2-butene; 2-chloro-2-butene and 4-chloro-lbutene are inactive. The four mutagenic compounds have allylic structures. The vinylic-type compound, 2-chloro-2-butene, may be metabolically activated, whereas 4-chloro-l-butène is inactive even in the presence of the S9 system.

Costa et al. (235) exposed a group of albino rats to an atmosphere containing CC14 for 7 months. Among the 30 survivors 10 had liver nodules diagnosed histologically as early or established liver carcinomas. The details of the study and the type of control were not given. 3 ml/kg of a 50% solution of CC14 in corn oil. A low incidence of small hepatomas was observed in Buffalo strain rats of both sexes treated at the age of 24 or 52 weeks (236). The hepatocarcinogenicity of CC14 in Buffalo strain rats was enhanced by simultaneous administration of 3-methylcholanthrene (238).

Trichlorofluoromethane (Freon 11) had no significant carcinogenic effects 1 year after repeated subcutaneous injections into neonatal Swiss ICR/Ha mice (253). An NCI study (254) confirmed the lack of carcinogenicity of trichlorofluoromethane in the mouse; B6C3Fj mice that received average oral doses of 1962 and 3925 mg/kg/day, 5 days/week for 78 weeks, did not develop tumors attributable to the treatment. Osborne-Mendel rats were also used in the study. However, the doses administered (488 and 977 mg/kg/day for males; 538 and 1077 mg/kg/day for females) caused a high rate of early deaths so that an insufficient number of rats survived long enough to rule out the possibility of late-developing tumors.

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Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos

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