Read e-book online Advances in Biology and Therapy of Multiple Myeloma: Volume PDF

By Ross Brown, P. Joy Ho, John Gibson, Douglas Joshua (auth.), Nikhil C. Munshi, Kenneth C. Anderson (eds.)

ISBN-10: 1461452597

ISBN-13: 9781461452591

ISBN-10: 1461452600

ISBN-13: 9781461452607

Despite the advances in traditional, novel agent and excessive dose chemotherapy a number of myeloma (MM) is still incurable. on the way to conquer resistance to present treatments and enhance sufferer final result, novel biologically-based remedy methods are being constructed. present translational learn in MM concentrating on the improvement of molecularly-based mix treatments has nice promise to accomplish excessive frequency and sturdy responses within the majority of sufferers. significant advances are making this aim attainable. First, fresh advances in genomics and proteomics in MM have allowed for elevated realizing of affliction pathogenesis, pointed out novel healing ambitions, allowed for molecular category, and supplied the clinical motive for combining precise treatments to extend tumor phone cytotoxicity and abrogate drug resistance. moment, there's now an elevated realizing of ways adhesion of MM cells in bone marrow (BM) extra affects gene expression in MM cells, in addition to in BM stromal cells (BMSCs). due to those advances in oncogenomics at the one hand and elevated knowing of the function of the BM within the pathogenesis of MM at the different, a brand new therapy paradigm concentrating on the tumor telephone and its BM microenvironment to beat drug resistance and increase sufferer final result has now been built. Thalidomide, lenalidomide, and Bortezomib are 3 brokers which goal the tumor cellphone in its microenvironment in either laboratory and animal types and that have speedily translated from the bench to the bedside. Ongoing efforts are utilizing oncogenomics and telephone signaling experiences to spot subsequent new release of cures in MM at the one hand, and to notify the layout of blend trials at the different. This new paradigm for overcoming drug resistance and bettering sufferer final result in MM has nice promise not just to alter the common historical past of MM, but additionally to function a version for particular therapeutics directed to enhance consequence of sufferers with MM.

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However, clinical response is still a rare event, occurring only in a minority of treated patients, suggesting that the elicited or enhanced immunity is still too weak to cause significant tumor destruction. Thus far, although no active immunotherapy maneuver has yet proven to be effective in the clinic, intensive efforts are underway to develop such an approach. Experiments in animal models have shown that vaccination against actively growing tumors is much more difficult to accomplish [113, 114].

However, clinical response is still a rare event, occurring only in a minority of treated patients, suggesting that the elicited or enhanced immunity is still too weak to cause significant tumor destruction. Thus far, although no active immunotherapy maneuver has yet proven to be effective in the clinic, intensive efforts are underway to develop such an approach. Experiments in animal models have shown that vaccination against actively growing tumors is much more difficult to accomplish [113, 114].

One patient also had an anti-Id humoral response. Titzer and coworkers [36] treated 11 patients with advanced MM with Id-pulsed, CD34+ stem cell–derived DCs and GM-CSF. After vaccination, three out of ten analyzed patients showed an increased anti-Id antibody titer, and four out of the ten patients had an Id-specific T-cell response measured by ELISPOT assay. To improve the efficacy of DC vaccination in myeloma, we investigated the use of Id-pulsed mature DCs administered subcutaneously. Five patients with stable partial remission following high-dose chemotherapy were vaccinated at least 4 months posttransplantation [37].

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Advances in Biology and Therapy of Multiple Myeloma: Volume 2: Translational and Clinical Research by Ross Brown, P. Joy Ho, John Gibson, Douglas Joshua (auth.), Nikhil C. Munshi, Kenneth C. Anderson (eds.)


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