By David M. Panchision (auth.), Donald G. Phinney (eds.)
This is finished review of a necessary sector of clinical enquiry, which covers a large spectrum of concerns. With contributions from a few of the key researchers within the box, grownup Stem Cells: Biology and strategies of study bargains readers a ancient standpoint in addition to precise insights into state-of-the-art strategies. the quantity contextualizes the hot discovery of stem/progenitor mobile populations resident in lots of grownup tissues and organs. It confronts the complexities scientists face in attempting to validate those cells, whereas it additionally describes and severely evaluates the equipment at the moment used to evaluate stem telephone self-renewal. The chapters additionally search to tell apart this procedure from different features of mobilephone survival, resembling the law of lifestyles span, senescence, and immortalization at a molecular point.
The monograph starts off with a piece that study the elemental biology of grownup stem cells, together with chapters at the rising function of microRNAs in regulating their destiny and the molecular mechanisms that govern their self-renewal, the e-book strikes directly to research the various methodologies hired in characterizing those elusive components of our genetic makeup. the second one part info in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem mobilephone paradigm, and considers the functionality of ABC transporters and aldehyde dehydrogenase in grownup stem-cell biology. the ultimate part shifts the focal point to the life-span law and immortalization and contours a bankruptcy at the melanoma stem mobile paradigm.
This is an authoritative quantity on one of many frontiers of genetic study, and may function a worthwhile source, not only for demonstrated scientists but in addition for these now getting into the sector of stem telephone biology.
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Extra info for Adult Stem Cells: Biology and Methods of Analysis
Chen HL, Panchision DM (2007) Concise review: bone morphogenetic protein pleiotropism in neural stem cells and their derivatives – alternative pathways, convergent signals. Stem Cells 25:63–68. Chen HL, Pistollato F, Hoeppner DJ et al (2007) Oxygen tension regulates survival and fate of mouse CNS precursors at multiple levels. Stem Cells 25:2291–2301. Chen X, Vega VB, Ng HH (2008) Transcriptional regulatory networks in embryonic stem cells. Cold Spring Harb Symp Quant Biol 73:203–209. Chojnacki AK, Mak GK, Weiss S (2009) Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?
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Knoepfler PS, Kenney AM (2006) Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle 5:47–52. Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149–184. Kuhn HG, Winkler J, Kempermann G et al (1997) Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci 17:5820–5829. Kuwabara T, Hsieh J, Muotri A et al. (2009) Wnt-mediated activation of NeuroD1 and retroelements during adult neurogenesis.
Adult Stem Cells: Biology and Methods of Analysis by David M. Panchision (auth.), Donald G. Phinney (eds.)