By Mark Ptashne
The 1st variation of Mark Ptashne's 1986 ebook describing the rules of gene rules in phage lambda grew to become a vintage in either content material and shape, environment a customary of readability and specific prose that has not often been bettered. This version is a reprint of the unique textual content, including a brand new bankruptcy updating the tale to 2004. one of the notable new advancements are contemporary findings on long-range interactions among proteins sure to largely separated websites at the phage genome, and a close description of ways gene activation works.
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The 1st variation of Mark Ptashne's 1986 ebook describing the foundations of gene rules in phage lambda turned a vintage in either content material and shape, atmosphere a typical of readability and exact prose that has not often been bettered. This variation is a reprint of the unique textual content, including a brand new bankruptcy updating the tale to 2004.
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Extra info for A Genetic Switch: Phage Lambda Revisited
1981). λ repressor and cro-components of an efficient molecular switch. Nature 294, 217-233. 3. Lwoff, A. (1953). Lysogeny. Bacteriol. Rev. 17, 269. 4. Ptashne, M. (1984). Repressors. Trends Biochem. Sci. 9, 142-145. 5. T. (1976). Autoregulation and function of a repressor in bacteriophage λ. Science 194, 156161. 6. Ptashne, M. and Gilbert, W. (1970). Genetic repressors. Sci. Am. 222, 36-44. 7. T. (1980). How the λ repressor and Cro work. Cell 19, 1-11. 8. Roberts, J. and Devoret, R. (1983). Lysogenic induction.
19. Repressor is constantly being synthesized as the cells grow and divide, whereas the cro gene remains silent. If the repressor concentration increases—as might happen, for example, were cell division temporarily inhibited—repressor would bind also to OR3 to turn its own gene off. As the cell began dividing again and the repressor concentration dropped to the proper level the cl gene would resume functioning, providing more repressor. Thus a constant level of repressor is maintained in the cell, despite fluctuations in growth rate.
The black diamond indicates the axis of symmetry. 1. The six operator sites recognized by λ repressor and Cro. The sites are listed in the order of their intrinsic affinities for a λ repressor dimer. The central base pair, the axis of symmetry, is shown in blue. 2. The 12 half-sites of the λ operators. 1 is represented here as two half-sites. Only one strand is written for each half-site. 1, reading right to left. The positions in the operator are numbered at the top. At the bottom the frequency with which each base appears is given for each position.
A Genetic Switch: Phage Lambda Revisited by Mark Ptashne